Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 701-56-4, name is 4-Methoxy-N,N-dimethylaniline, A new synthetic method of this compound is introduced below., Recommanded Product: 4-Methoxy-N,N-dimethylaniline
General procedure: N,N-dimethylaniline (0.4 mmol, 1.0 equiv.) and diphenyliodonium salts (0.8 mmol, 2.0 equiv.) were added to a dried Schlenk tube. The tube was degassed with Nitrogen for three times. Then Toluene (3.0 mL) were added via a syringe, finally add 0.8 mL LiHMDS (0.8 mmol, 2.0 equiv.) 1 mol/L solution in THF under ice bath conditions. The mixture was stirred at 110 oC for 16 h, and then cooled down to room temperature. The crude products were directly purified using flash column chromatography on silica gel (petroleum ether/ethyl acetate 100:1 as eluants) to afford the desired product.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Zhang, Zhiang; Wu, Xunshen; Han, Jianwei; Wu, Wenjun; Wang, Limin; Tetrahedron Letters; vol. 59; 18; (2018); p. 1737 – 1741;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem