Related Products of 888327-32-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 888327-32-0, name is 4-Bromo-1-(difluoromethoxy)-2-methylbenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
EXAMPLE 77 Preparation of: 2-amino-5-[4-(difluoromethoxy)-3-methylphenyl]-3-methyl-5-(3-methylphenyl)- 3,5-dihydro-4H-imidazol-4-oneStep 1 : 1-(difluoromethoxy)-2-(2-fluoroethyl)-4-(phenylethvnyl)benzene; In a 50 mL round-bottomed flask was placed 4-bromo-1-(difluoromethoxy)-2- methylbenzene (0.8 g, 3.37 mmol) and DMF (6.75 mL) was added to give a colorless solution.1-Ethynyl-3-methylbenzene (0.436 mL, 3.37 mmol) and triethylamine (2.352 mL, 16.87 mmol) were added. The reaction was degassed by bubbling with N2.Bis(triphenylphosphine)palladium(ll) chloride (0.118 g, 0.169 mmol) was added and N2 bubbling was continued. Copper iodide (0.032 g, 0.169 mmol) was added. The reaction was heated to 60 C for 12h. The reaction was cooled and partitioned between ether (70 mL) and 1MHCI (50 mL). The organic was washed with 1 M HCI (50 mL) and brine (2 x 50 mL). The organic layer was dried over Na2SO4. The crude was purified by flash chromatography (100% hexanes) to
The synthetic route of 4-Bromo-1-(difluoromethoxy)-2-methylbenzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; WYETH; WO2008/115552; (2008); A1;,
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