Adding a certain compound to certain chemical reactions, such as: 1462-37-9, name is ((2-Bromoethoxy)methyl)benzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1462-37-9, Recommanded Product: ((2-Bromoethoxy)methyl)benzene
To a solution of 3-hydroxybenzaldehyde (2.90 kg, 23.75 mol), and ((2- bromoethoxy)methyl)benzene (4.26 kg, 19.79 mol) in DMF (9.3 L) was added K2C03 (3.83 kg, 27.70 mol). The reaction mixture was stirred at r.t. for 24 h. Water (15 L) and tert-butyl methyl ether (23 L) were added to the reaction mixture. The organic phase was separated and washed with 1 N NaOH (2X15 L) and water (15 L) sequentially, and then concentrated to a minimum. Ethanol (23 L) was added and the solution was concentrated under vacuum to afford the desired product (4.7 kg, 93percent) as a colourless oil. 1 H NMR (400 MHz, DMSO-c/6): 9.98 (s, 1 H), 7.55-7.52 (m, 2H), 7.46 (s, 1 H), 7.36-7.34 (m, 4H), 7.32-7.26 (m, 2H), 4.57 (s, 2H), 4.25-4.22 (t, J = 4.4 Hz, 2H), 3.80-3.78 (t, J = 4.4 Hz, 2H). LCMS: [M+Na]+ = 279
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Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; ANACOR PHARMACEUTICALS, INC.; ALLEY, M.R.K. (Dickon); HERNANDEZ, Vincent S.; PLATTNER, Jacob J.; LI, Xianfeng; BARROS-AGUIRRE, David; GIORDANO, Ilaria; WO2015/21396; (2015); A2;,
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