Application of 39538-68-6, These common heterocyclic compound, 39538-68-6, name is 2-Methoxy-4-methylaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of cupric bromide (6.35 g; 28.4 mmol) in acetonitrille (25 ml_) was added tert- butyl nitrite (2.85 ml 24.06 mmol) and the mixture was heated at 65^ under a nitrogen atmosphere. A solution of 2-methoxy-4-methylaniline (3 g; 21 .87 mmol) in acetonitrile (25 ml_) was added carefully and the mixture was stirred for 20 min at 65 ‘O. The solvent was removed under reduced pressure and the residue was dissolved in ethyl acetate and washed (x 3) with an aqueous solution of ammonia 5%, water, a solution of ethylenediaminetetraacetic acid, water, brine and the mixture was concentrated under reduced pressure. Purification by flash-chromatography on silica gel using a gradient of ethyl acetate (2 – 50 %) in heptane furnished 2.32 g (53 %) of the title compound as a yellow oil.
Statistics shows that 2-Methoxy-4-methylaniline is playing an increasingly important role. we look forward to future research findings about 39538-68-6.
Reference:
Patent; KATHOLIEKE UNIVERSITEIT LEUVEN; CHALTIN, Patrick; DEBYSER, Zeger; DE MAEYER, Marc; MARCHAND, Arnaud; MARCHAND, Damien; SMETS, Wim; VOET, Arnout; CHRIST, Frauke; WO2011/15641; (2011); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem