Some common heterocyclic compound, 105404-89-5, name is 2,7-Dibromo-3,6-dimethoxynaphthalene, molecular formula is C12H10Br2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 2,7-Dibromo-3,6-dimethoxynaphthalene
0.125 mol [intermediate 1-1] at room temperature,43.4 g and (4-chloro-2-fluorophenyl) boronic acid 0.301 mol, 52.5 g and Ce2CO3 0.815 mol, 266 g and TTP (tetrakis(triphenylphosphine)palladium(0)) 8 mol% 11.6 g was added with 500 mL of 1,4-dioxane and refluxed. After 4 hours, the reaction was cooled to room temperature, 500 ml of H2O was added, and extracted with EA.After filtration, the obtained solid was recrystallized from EA (ethyl acetate) and Hx (normal hexane) to obtain 0.09 mol of [Intermediate 1-2] and 41.0 g (yield 73%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 105404-89-5, its application will become more common.
Reference:
Patent; LG Chem, Ltd.; Gu Gi-dong; Kim Myeong-gon; Keum Su-jeong; Yoon Jeong-min; (52 pag.)KR2019/111688; (2019); A;,
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