Some common heterocyclic compound, 6443-69-2, name is 1,2,3-Trimethoxy-5-methylbenzene, molecular formula is C10H14O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 6443-69-2
Compound 1 (1.82 g, 0.01 mol), NaBr (1.13 g, 0.011 mol) and sulfuric acid (2 mL) weredissolved in ethanol (8 mL). The mixture was treated dropwise with 30% H2O2 (5 mL,0.045 mol) at room temperature over a period of 1 h. Then the mixture was quenchedwith water (10 mL) and extracted with petroleum ether (15mL 3). The organic layerswere combined and evaporated in vacuo to afford 2, 2.60 g, 100%, yellowish oil.IR: (cm1) 3490, 2934, 1570, 1466, 1402, 1109, 824. 1H NMR (400MHz, CDCl3):d 6.61 (s, 1H, ArH), 3.89 (s, 3H, OCH3), 3.86 (s, 3H, OCH3), 3.84 (s, 3H, OCH3),2.37 (s, 3H, CH3). 13C NMR (101 MHz, CDCl3): d 152.2, 150.8, 141.1, 133.4, 110.8,109.5, 61.1 (OCH3), 60.9 (OCH3), 56.1 (OCH3), 23.2(CH3). The spectroscopic data arein accord with the literature.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6443-69-2, its application will become more common.
Reference:
Article; Qiu, Yong-Fu; Yan, Yi-Yu; Lu, Bin; Tang, Lei; Zhai, Yu-Lin; Chen, Ke-Xin; Wang, Jin; Organic Preparations and Procedures International; vol. 51; 6; (2019); p. 602 – 605;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem