Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1836-62-0, name is 2-(2-Methoxyphenoxy)ethylamine, A new synthetic method of this compound is introduced below., SDS of cas: 1836-62-0
Example -4: Preparation of carvedilol In a dry reaction flask charged 25.0 g 4 – (2,3-epoxy propoxy) carbazole (0.104 moles), 39.35 g of 2 – (2- methoxy phenoxy) ethylamine (0.235moles) in 250 ml dimethyl sulfoxide. The temperature of the reaction mass was raised to about 70C under stirring and maintaining the reaction mixture at 68 – 72C for 18 – 20 hrs. The reaction mass was cooled to about 30C and quenched the reaction mass in 250 ml water, stirred and extracted the resultant solution in 250 ml dichloromethane. The organic layer was separated and washed with aqueous sulphuric acid till pH of the washings about 7.0 – 8.0. The organic layer was separated and further adjusted the pH with the aqueous sulfuric acid to 4.0 – 4.5 to precipitate carvedilol sulphate salt. The precipitated salt was filtered and taken in 300 ml ethyl acetate and made alkaline with 10% sodium carbonate solution. The reaction mass was stirred and separated the organic layer. The ethyl acetate was distilled under vacuum, and 330 ml toluene was added to it. The solid obtained was filtered and crystallized from ethyl acetate to obtain pure carvedilol. Yield = 58 – 62%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; IPCA Laboratories Limited; EP1741700; (2007); A1;,
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