Electric Literature of 645-36-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 645-36-3 name is 2,2-Diethoxyethanamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
First, 1-naphtaldehyde (1.6 g, 10 mmol) and 2,2-dietoxyethanamine (1.3 g, 10 mmol) were mixed, and the mixture was stirred at 100C for from 30 min to 1 h. After allowed to cool, the reaction mixture was mixed with EtOH (25 mL), and the resulting mixture was stirred and made homogeneous. Next, a small amount of NaBH4 (0.38 g, 10 mmol) was gradually added and the mixture was then stirred at room temperature for from 1 h to overnight. After completion of the reaction, EtOH was distilled away while the mixture was concentrated under reduced pressure. (An appropriate amount of) Water was added to the resulting residue, and a product was extracted with AcOEt. A separated organic layer was washed with saturated saline and dried with Na2SO4. After that, the sample was filtered and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (AcOEt/hexane = 5/1) to yield compound 1 (2.3 g, 8.5 mmol, 85%) as colorless transparent liquid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,2-Diethoxyethanamine, and friends who are interested can also refer to it.
Reference:
Patent; National University Corporation Tottori University; KanonCure, Inc.; SHIOTA, Goshi; ITABA, Noriko; KANKI, Keita; SETO, Kenzo; SHIMIZU, Hiroki; KOUNO, Yohei; KUNITA, Shinya; ADUMI, Zyunya; SAKABE, Tomohiko; ABE, Kenichiro; MORIMOTO, Minoru; OKA, Hiroyuki; (77 pag.)EP3150207; (2019); B1;,
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