Synthetic Route of 2062-98-8, A common heterocyclic compound, 2062-98-8, name is Perfluoro(2-methyl-3-oxahexanoyl) fluoride, molecular formula is C6F12O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In an argon atmosphere, put 0.50 g (4.2 mmol) of 4-hydroxystyrene into a three-necked flask, add 20 mL of dichloromethane, and add 1.99 g (6 mmol) of hexafluoropropylene oxide di containing acid fluoride end groups while stirring. Polymer (CF3CF2CF2OCF (CF3) COF, provided by Zhejiang Huanxin Fluoro Material Co., Ltd., recorded as FEOCOF), after the addition, 0.05 mL (0.0007 mmol) DMF was added, and 0.4 mL (0.003 mmol) of dry After triethylamine was added dropwise, the reaction was stirred at 40 C for 4h. After the reaction, 20 mL of deionized water was added and extracted with dichloromethane (20 mL × 3). The organic phases were combined and dried over MgSO 4, filtered, and rotary evaporated to obtain a crude product. The crude product was separated by silica gel column chromatography (washed with petroleum ether). Remover) to obtain a colorless slightly viscous liquid, the target product, with a yield of 99.5%
The synthetic route of 2062-98-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shaanxi Normal University; Yang Le; Chen Jiangang; Liu Zhaotie; Zhang Qiyu; Li Ruiqing; Shen Shukun; Liu Zhongwen; (11 pag.)CN110776426; (2020); A;,
Ether – Wikipedia,
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