Electric Literature of 111-95-5,Some common heterocyclic compound, 111-95-5, name is Bis(2-methoxyethyl)amine, molecular formula is C6H15NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To an ethanolic solution (30 ml) of p-chlorophenol (30 mmol, 3.86 g), bis(2-methoxyethyl)amine (90 mmol, 11.99 g) was added dropwise with constant stirring. After 30 min, 37% (w/v) formalin solution (90 mmol, 7.5 ml) was added to it. The resulting mixture was stirred for 1 h at room temperature and then refluxed for 24 h. Then the same procedure-was followed as for HL1. The liquid ligand was further purified by flash column chromatography (silica gel, hexane:ethylacetate:triethylamine=100:5:1) to afford the desired beta-aminophenol.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Bis(2-methoxyethyl)amine, its application will become more common.
Reference:
Article; Sanyal, Ria; Chakraborty, Prateeti; Zangrando, Ennio; Das, Debasis; Polyhedron; vol. 97; (2015); p. 55 – 65;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem