Reference of 588-63-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 588-63-6 name is (3-Bromopropoxy)benzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: A solution of alkyl bromide (1 equiv) and sodium azide (2.5 equiv) in DMF (0.14 M) was stirred under argon at 80 °C for 18 h. After cooling at room temperature, the reaction mixture was diluted in Et2O and washed with water (×6). The organic phase was dried over anhydrous MgSO4, filtered, and concentrated in vacuo to give the corresponding pure azide without need of any further purification.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, (3-Bromopropoxy)benzene, and friends who are interested can also refer to it.
Reference:
Article; Maury, Julien; Feray, Laurence; Bertrand, Michele P.; Kapat, Ajoy; Renaud, Philippe; Tetrahedron; vol. 68; 47; (2012); p. 9606 – 9611,6;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem