Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 10541-78-3, name is 2-Methoxy-N-methylaniline, A new synthetic method of this compound is introduced below., HPLC of Formula: C8H11NO
General procedure: A mixture of secondary amine 1 (200 mg, 1 equiv), polyformaldehyde 2 (1.5 equiv) and the activated alkene 3 (1.1 equiv) was dissolved in acetonitrile (2 mL). The solution was stirred at room temperature for 3 days until the starting secondary amine 1 was no longer detected by TLC (revealed with an ethanolic solution of vanillin-sulfuric acid or iodine). After the excess of solvent was removed under reduced pressure, the oily material obtained was purified by column chromatography on silica gel (70-230 mesh), using CHCl3:MeOH mixtures of (30:1, 20:1 or 15:1) as eluent.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Abonia, Rodrigo; Castillo, Juan C.; Garay, Alexander; Insuasty, Braulio; Quiroga, Jairo; Nogueras, Manuel; Cobo, Justo; D’Vries, Richard; Tetrahedron Letters; vol. 58; 15; (2017); p. 1490 – 1494;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem