Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 13101-88-7, name is 6-Methoxynaphthalen-2-amine, A new synthetic method of this compound is introduced below., Quality Control of 6-Methoxynaphthalen-2-amine
Weigh compound 6-methoxy-2-naphthyl-amine (7g, 0.04044mol), triethylamine (6g, 0.06067mol) in 100mL reaction flask, a solution of methylene chloride was added to the reaction flask of 15mL at 0 the reaction conditions under 15min; dropwise added methanesulfonyl chloride (7g, 0.06067mol), under reaction conditions 0 30min, TLC plate monitor, the reaction was complete, adding an appropriate amount of aqueous sodium hydroxide solution, extracted with ethyl acetate and saturated brine dried over anhydrous sodium sulfate, and spin dry, column chromatography (PE: EA = 2: 1), give a purple solid 5.6g, yield 55.2%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; East China University of Science and Technology; Li, Hongling; Jiang, Hualiang; Xu, Yufang; Li, Jia; Zhao, Zhenjang; Li, Jingya; Xu, Hongling; Li, Shiliang; (64 pag.)CN105566276; (2016); A;,
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