Reference of 157869-15-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 157869-15-3 as follows.
General experimental procedure for tandem addition-cyclization of 2-alkynylbenzenamines (1) with CS2: A solution of 2-alkynylbenzenamines 1 (0.30 mmol), CS2 (3.0 mmol, 10 equiv), AgNO3 (5 mol %), DABCO (1.2 equiv) in DMF (2.0 mL) was stirred at room temperature. After completion of reaction as indicated by TLC, the reaction was quenched with water (10 mL), extracted with EtOAc (2×10 mL), and dried by anhydrous Na2SO4. Evaporation of the solvent followed by purification on silica gel provided the corresponding 4-benzylidene-4H-benzo[d][1,3]thiazine 2a.
According to the analysis of related databases, 157869-15-3, the application of this compound in the production field has become more and more popular.
Reference:
Article; Ding, Qiuping; Liu, Xianjin; Yu, Jinsheng; Zhang, Qiulan; Wang, Dan; Cao, Banpeng; Peng, Yiyuan; Tetrahedron; vol. 68; 21; (2012); p. 3937 – 3941;,
Ether – Wikipedia,
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