Reference of 33311-29-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 33311-29-4, name is 4-(2-Methoxyethoxy)aniline, This compound has unique chemical properties. The synthetic route is as follows.
To a solution of (R)-3-(4-oxo-piperidin-1-yl)-butyronitrile (492 mg, 2.95 mmol) and 4-(2-methoxy-ethoxy)-phenylamine (492 mg, 2.95 mmol) in CH2Cl2 (12 mL) and glacial AcOH (14 drops) was added NaBH(OAc)3 (758 mg, 3.58 mmol) and the reaction stirred at room temperature overnight. Purification of the crude product by column chromatography on silica gel (CH2Cl2/MeOH, 96:4) gave the desired aniline (R)-3-{4-[4-(2-methoxy-ethoxy)-phenylamino-piperidin-1-yl}-butyronitrile (0.72 g, 94%) as an orange oil.
The chemical industry reduces the impact on the environment during synthesis 4-(2-Methoxyethoxy)aniline. I believe this compound will play a more active role in future production and life.
Reference:
Patent; AnorMED Inc.; US2005/277668; (2005); A1;,
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