Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5961-59-1, name is 4-Methoxy-N-methylaniline, A new synthetic method of this compound is introduced below., Recommanded Product: 5961-59-1
Example 1: Key Intermediate (S)-N-(1-(4-methoxyphenyl)(methyl)amino)-1-carbonyl-3-phenyl-2-yl)propynamide (4 Preparation of The starting material Boc-L-phenylalanine (1) (8.75 mmol, 2.3 g) was added to 15 mL of anhydrous dichloromethane solution. To this solution was then added 1H-benzotriazol-1-yloxytripyrrolidinylhexafluorophosphate (10.9 mmol, 5.7 g). After stirring for 0.5 h under ice bath, N,N-diisopropylethylamine (21.87 mmol, 3.61 mL) and N-methyl-4-aminoanisole (7.29 mmol, 1.0 g) were added to remove the ice bath. Stir at room temperature for 12 h. After the reaction is completed, the solvent is distilled off under reduced pressure, then saturated sodium bicarbonate solution is added to the bottle residue, and ethyl acetate is extracted; the organic layer is separated, 1N HCl solution is added, and ethyl acetate is extracted; the organic layers are combined and saturated. The brine was washed and the organic phase was dried over anhydrous sodium sulfate; Filtration and evaporation of the solvent under reduced pressure gave the intermediate compound tert-butyl-(S)-(1-((4-methoxyphenyl)(methyl)amino)-1-oxo-3-phenylpropyl- 2-Carboxylic acid (2) Crude 2.63 g, yellow oil, 94% yield,
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Shandong University; Zhan Peng; Wu Gaoshan; Liu Xinyong; Li Guoxiong; Kang Dongwei; Yu Ji; Sun Lin; (25 pag.)CN108033952; (2018); A;,
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