Synthetic Route of 592-55-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 592-55-2 as follows.
To a stirred solution of pentane 1,5-diol 1 (11 g, 105.76 mmol) in N,N-dimethyl formamide (30 mL) was treated with 60 % of NaH (4.5 g, 116.34 mmol) at 0 C and stirred at room temperature for 30 min.1-bromo-2-ethoxyethane 2 (12 mL, 105.76 mmol) in N, N- dimethyl formamide (20 mL) was added to the above reaction mixture at 0 C and stirred at room temperature and stirred for 16 h under argon atmosphere. The reaction mixture was quenched with ice water (200 mL) and extracted with ethyl acetate (3 x 250 mL). Combined organic layers were washed with brine (2 x 100 mL) and dried over Na2SO4, evaporated under reduced pressure. Crude residue was purified by column chromatography (100-200 silica gel) using 30 % ethyl acetate in hexanes to afford 5-(2-ethoxyethoxy) pentan-1ol 3 (5.1 g, 28.97 mmol, 27 % yield) as an oily liquid. TLC system: 70 % ethyl acetate in hexanes – Rf: 0.50; LCMS: m/z = 199.12 (M+Na) +
According to the analysis of related databases, 592-55-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; COCRYSTAL PHARMA, INC.; JACOBSON, Irina, C.; LEE, Sam SK; FEESE, Michael, David; (206 pag.)WO2020/23813; (2020); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem