Related Products of 321-28-8,Some common heterocyclic compound, 321-28-8, name is 1-Fluoro-2-methoxybenzene, molecular formula is C7H7FO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Add 3-fluoroanisole (85.0g, 0.67mol), tetrahydrofuran (3540mL), tetramethylethylenediamine (78.3g, 0.67mol) at room temperature,Replace with nitrogen three times, turn on stirring,Cooled to -50 ~ -78 , was added dropwise a solution of sec-butyllithium (870mL, 1.3M), after the addition was complete stirring incubated 2 to 3 hours, a solution of N, N- dimethylformamide (67.5g, 0.92 mol), heat and stir for 1 hour,After the reaction was completed, a 13% acetic acid aqueous solution (1464 g) was added dropwise at -50 to -78 C, and the layers were separated. The aqueous phase was extracted with ethyl acetate (350 mL * 3), and the organic phases were combined.After washing with water (500mL), 1N hydrochloric acid,The organic phase is concentrated to no droplets,A pale yellow mixture was obtained and crystallized from methyl tert-butyl ether (150 mL) to give a white solid,Drying gave compound II (57.7 g, 57.3%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Fluoro-2-methoxybenzene, its application will become more common.
Reference:
Patent; Shanghai Bopunuo Science And Technology Co., Ltd.; Guo Peng; Ji Changyou; Wang Jun; Zhang Dong; Liang Shoushan; Zhu Wenfeng; (15 pag.)CN110759870; (2020); A;,
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