Reference of 6298-96-0,Some common heterocyclic compound, 6298-96-0, name is 1-(4-Methoxyphenyl)ethylamine, molecular formula is C9H13NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The solid compound A (422 g) obtained in the above step was dissolved in 2.0 L of methanol and 10 L of a reaction flask was added.Lithium hydroxide (26 g) was weighed, dissolved in 2.0 L of pure water, and an aqueous solution of lithium hydroxide was added to the reaction flask. The temperature was controlled at 25-30 C for 1 hour, and the reaction was complete.Add water (4.0L) to the reaction flask, with 1N hydrochloric acid to adjust rhoH- = 2-3, a large number of solid precipitation, the solid material filter out, filter, with 2.9L dichloromethane solid solution Clear, magnetic stirrer slowly stirring.Weigh the s-p-methoxyphenylethylamine (151g), dissolved in 1.0L dichloromethane, the amine solution slowly added to the solution, dropping 40-50 minutes, the temperature control at 18 ~ 22 C, After the dropwise addition, the mixture was allowed to stand for 1 hour, and a large amount of fine granular solid and flocculent solid were precipitated. The granular solid sank into the bottom of the container and the floc floats on the upper part of the solution.After overnight, the supernatant was carefully poured out and the bottom solid was filtered and dried at 35 C under reduced pressure to give compound C, solid: 271 g.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-(4-Methoxyphenyl)ethylamine, its application will become more common.
Reference:
Patent; Shanghai Jinhe Bio-pharmaceutical Co., Ltd.; Zhang Weizhong; Wang Quanyong; Cai Zhixia; Xie Bin; Feng Leiyu; Wu Yujuan; Tong Zebin; (12 pag.)CN106632368; (2017); A;,
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