In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1535-75-7, name is 2-(Trifluoromethoxy)aniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C7H6F3NO
Stepl : 1-azido-2-(trifluoromethoxy)benzene (27a) Concentrated HCl (7.9 mL) was added to a solution of 2-(trifluoromethoxy)aniline (1.1 mL, 7.9 mmol) in EtOAc (26 mL) at 0 C. After 10min, a solution of sodium nitrite (1.6 g, 23.7 mmol) dissolved in water (4.6 mL) was added slowly over 5 min. The mixture was stirred for 30min, and then treated with a solution of sodium azide (1.5 g, 23.7 mmol) in water (5.3 mL) slowly over 5min. The reaction was stirred for 1 h then treated with phosphate buffer saline (pH 7.4, 50 mL). The mixture was extracted with EtOAc, the organics were washed with brine, dried over Na2S04 and concentrated to give compound 27a.
The synthetic route of 1535-75-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GILEAD SCIENCES, INC.; KINZEL, Olaf; KREMOSER, Claus; BLOMGREN, Peter, A.; CURRIE, Kevin, S.; KROPF, Jeffrey, E.; SCHMITT, Aaron; WATKINS, William, J.; XU, Jianjun; GEGE, Christian; (92 pag.)WO2016/96116; (2016); A1;,
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