Electric Literature of 37895-73-1, These common heterocyclic compound, 37895-73-1, name is 1,2-Dibromo-4,5-dimethoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A Schlenk flask was charged under argon with 1 equiv of dihaloarene, 0.2 equiv of CuI, 0.22 equiv of Cy3PHBF4, and 0.1 equiv of PdCl2(PPh3)2. The flask was closed, evacuated, and filled with argon (the procedure was repeated thrice), 8 mL of DMF (per millimole of dihaloarene), 4 equiv of triethylamine, and 3 equiv of lactone 1a or 1b were added with a syringe, and the mixture was heated for 8 h at 100C. The mixture was cooled and concentrated under reduced pressure, and the products were isolated by column chromatography using heptane-ethyl acetateas eluent.
The synthetic route of 37895-73-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Ghochikyan; Samvelyan; Galstyan; Gevorgyan; Vardanyan; Grigoryan; Langer; Russian Journal of Organic Chemistry; vol. 53; 12; (2017); p. 1833 – 1839; Zh. Org. Khim.; vol. 53; 12; (2017); p. 1797 – 1803,7;,
Ether – Wikipedia,
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