Adding a certain compound to certain chemical reactions, such as: 1978-39-8, name is 5-Fluoro-2-methoxyaniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1978-39-8, Computed Properties of C7H8FNO
General procedure: A primary amine (17.8 mmol) was dissolved/suspended in acetonitriie (50 ml) and then heated to reflux temperature. Then 2,6-lutidine (20 ml, 173 mmol) was added. A solution of DMP3C-BF4 (5.04 g, 9.88 mmol) was dissolved in acetonitriie (250 ml) and then added slowly dropwise (1 drop per 5-10 s) to the hot solution of the phenol compound. The addition was allowed to proceed overnight (16 h). The red reaction mixture was analyzed by MALDI-TOF (dithranol matrix) and this analysis indicated that no starting material was present. The reaction mixture was allowed to cool down, and then poured into an acidified KPF6 solution (10 ml 2 M HCI in 1500 ml 0.2 M KPF6) upon vigorous stirring. A red precipitate formed and the suspension was gen-tly stirred for 15 min and then filtered . The filtrate was washed with HCI solution (2 M), then with water, and finally with heptane until the heptane phase was nearly colorless. The red sticky mass was dissolved in a minimum of CH2CI2 through the filter. The product was precipitated with heptane and filtered off and washed with heptane (2 x 100 ml). The product was dissolved in a minor amount of acetonitrile and poured onto diethyl ether upon stirring. The red precipitate was allowed to form for 15 min, filtered off, and then washed with ether (2 x 100 ml). The red sticky product was collected and dissolved in CH2CI2. The CH2CI2 was removed by evaporation yielding 17 g of red-gray fine powder. The red powder was suspended in pure water and stirred overnight. The red powder was filtered off, washed with water, and sucked dry. The sticky red product was dissolved in acetonitrile through the funnel and then the solvent was removed by evaporation. The red powder was collected and dried on an oil pump for 1 day.
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Reference:
Patent; KØBENHAVNS UNIVERSITET; LAURSEN, Bo V.; ROSENBERG, Martin; SØRENSEN, Thomas Just; WO2015/58777; (2015); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem