Some common heterocyclic compound, 2393-23-9, name is 4-Methoxybenzylamine, molecular formula is C8H11NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 2393-23-9
1-methyl-1H-imidazole-2-carbaldehyde (0.882 g, 8.019 mmol, 1.1 equiv) and (4-methoxyphenyl)methanamine (0.943mL, 7.29 mmol, 1 equiv) were added to a 250 mL round bottom flask containing activatedmolecular sieves in methanol (73 mL). Reaction mixture was stirred at room temperature (RT).After completion of reaction (3 h), as monitored by TLC, reaction mixture was cooled to 0oC,followed by the addition of sodium borohydride. After complete consumption of imine (17 h), asmonitored by TLC, reaction was quenched with water (25 ml) followed by filtration of molecularsieves, evaporation of methanol in-vacuo, and extraction with ethyl acetate (25 ml X 5). Thecombined organic layers were dried over anhydrous Na2SO4, decanted, followed by removal ofvolatiles in-vacuo. Crude mixture was purified by flash column chromatography using 25-100%EtOAc in hexanes providing 10a (1.27 g, 76%) as a yellow oil
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2393-23-9, its application will become more common.
Reference:
Article; Joshi, Madhur S.; Lansakara, Ashabha I.; Pigge, F. Christopher; Tetrahedron Letters; vol. 56; 23; (2015); p. 3204 – 3207;,
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