Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 126-38-5, name is 1-Bromo-2,2-dimethoxypropane, A new synthetic method of this compound is introduced below., name: 1-Bromo-2,2-dimethoxypropane
The thioamide from above (0.36 g, 1.63 mmol, 1.0 eq) was suspended in EtOH (10 mL, absolute) under argon at rt. 1-Bromo-2,2-dimethoxypropane (0.22 mL, 1.63 mmol, 1.0 eq) was added via syringe and stirring continued for 72 h at rt. The mixture was then heated to 70 C. for 16 h and concentrated in vacuo. Mass spectrometric analysis of the crude residue was consistent with a corresponding thiazole structure, and no further manipulation was performed before removal of the Boc protecting group in the next step. ESI-MS (m/z) 257 [M+H]+, 201 [M-tBu]+, 157 [M-Boc]+.
The synthetic route of 126-38-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Erickson, Shawn David; Baldwin, John J.; Dolle III, Roland Ellwood; Inglese, James; Ohlmeyer, Michael H.J.; Ho, Koc-Kan; Bohnstedt, Adolph C.; Kultgen, Steven G.; Conti, Paolo Giovanni Martino; Leysen, Dirk; van der Louw, Jaap; US2004/87601; (2004); A1;,
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