37895-73-1, name is 1,2-Dibromo-4,5-dimethoxybenzene, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C8H8Br2O2
A flask containing 4,5-dibromoveratrole (500 mg, 1.69 mmol), 4-fluorophenylboronic acid (946 mg, 6.76 mmol), Pd(OAc)2 (38 mg, 0.169 mmol), XPhos (161 mg, 0.338 mmol), and K2CO3 (1.4 g, 10.1 mmol) was degassed and dioxane (10 mL) and H2O (5 mL) were added. Reaction was refluxed at 102 C. overnight then cooled to RT and diluted with EtOAc. Solution was washed with saturated NaHCO3 solution followed by brine and organic layer was collected, dried over Na2SO4, and concentrated. Chromatography using ISCO max gradient 10% EtOAc/hexane yielded product as a white solid (525 mg, 95% yield); 1H NMR (400 MHz) (CDCl3) delta 7.12-7.08 (m, 4H), 6.96-6.91 (m. 6H), 3.97 (s, 6H); 13C NMR (100 MHz) (CDCl3) delta 161.6 (JC,F=244 Hz), 148.4, 137.3 (JC,F=3 Hz), 132.1, 131.4 (JC,F=8 Hz), 114.9 (JC,F=21 Hz), 113.6.
The synthetic route of 37895-73-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; LaVoie, Edmond J.; Arnold, Eddy; Bauman, Joseph D.; Kerrigan, John E.; Parhi, Ajit K.; Das, Kalyan; Kelley, Cody; Patel, Dishaben V.; US2015/322022; (2015); A1;,
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