Application of 929-75-9, A common heterocyclic compound, 929-75-9, name is 1,11-Diamino-3,6,9-trioxaundecane, molecular formula is C8H20N2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A two-necked flask equipped with a condenser and magnetic stirrer, flushed with dry argon, wascharged with compounds 14 or 15 (0.2 mmol), Pd(dba)2 (18.4 mg, 16 mol%), RuPhos (16.8 mg,18 mol%), 10 ml absolute dioxane was added followed by corresponding oxadiamine 3a-d (0.4mmol) and sodium tert-butoxide (1.2 mmol, 115 mg). The reaction mixture was stirred at refluxfor 24 h, cooled down to room temperature, the residue was filtered off and washed with 5 mldichloromethane. The combined organic fractions were evaporated in vacuo, the residue wasdissolved in 5 ml dichloromethane, washed by water (3×5 ml), dried over molecular sieves 4A,the solvent was evaporated in vacuo and chromatographed on silica gel using a sequence ofeluents: CH2Cl2, CH2Cl2/MeOH 100:1 – 3:1, CH2Cl2/MeOH/NH3aq 100:20:1 – 100:20:4.
The synthetic route of 929-75-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Chernichenko, Nataliya M.; Averin, Alexei D.; Beletskaya, Irina P.; Letters in Organic Chemistry; vol. 15; 5; (2018); p. 425 – 430;,
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