Synthetic Route of 36805-97-7,Some common heterocyclic compound, 36805-97-7, name is 1,1-Di-tert-butoxy-N,N-dimethylmethanamine, molecular formula is C11H25NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Preparation of ferf-butyl l-(3-chloropropy arboxylate; [0248] Indole-2-carboxylic acid (1 g, 3.71 mmol, 1 equiv) was suspended in toluene and the mixture was heated to refluxing temperatures. NN-dimethylformamide di-teri-butyl acetal (5.476 ml, 22.84 mmol, 4 equiv) was added dropwise to the refluxing mixture within 30 minutes.Refluxing was continued for an additional 30- 45 minutes after which it was cooled and stirred at ambient temperature for 16 h. The reaction was diluted with ether and the organic layer was washed with sodium bicarbonate (sat), water and brine. The ether layer was dried over MgSO i, filtered, concentrated in vacuo and purified using the Biotage flash chromatography system (SNAP 50g cartridge, R/= 0.4, gradient – 1 %-10% ethyl acetate in hexanes) to afford the tert-butyl lH-indole-2- carboxylate as a white powder (1.15 g, 86.8%); MS for Ci3H15N02 m/z 217.99 (M+H)+.
The synthetic route of 36805-97-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ALTOS THERAPEUTICS, LLC; LUEHR, Gary, W.; SUNDARAM, Arathi; JAISHANKAR, Priyadarshini; PAYNE, Philip, W.; DRUZGALA, Pascal; WO2011/160084; (2011); A1;,
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