Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 14804-31-0, name is 4-Bromo-1-methoxy-2-methylbenzene, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 14804-31-0
After starting the Grignard reaction by adding 25.0 ml 4-bromo2-methyl-anisole to a mixture of 30.2 g (1.24 mol) magnesium turnings and 650 ml THF, 150 ml 4-bromo2-methylanisole (total: 175.0 ml were added at a pace sufficient to maintain reflux temperature. The reaction mixture was heated to reflux for additional 5 h, cooled to r.t. and dropped at 0 C. within 1 h to a stirred solution prepared by mixing 904 g (500 ml, 4.19 mol) 1,4-dibromo-butane in 1000 ml THF with a freshly prepared solution of 1.28 g (60.0 mmol) LiCl and 4.00 g (29.8 mmol) Cu(II)Cl2 in 140 ml THF. Stirring was continued for 12 h at r.t. followed by the addition of 400 ml of a 20% ammonium chloride solution and 200 ml ethyl acetate. The water phase was extracted twice with 250 ml ethyl acetate, all organic phases were combined, dried over sodium sulphate and evaporated. The resulting oil was fractionated by vacuum distillation. Yield: 226.3 g (71%), b.p. 131-134 C./0.01 mbar. 1H-NMR(400 MHz, D6-DMSO): delta=1.60(quintet, 2H, C2-CH2-Ph), 1.82(quintet, 2H, C2-CH2-Br), 2.23(s, 3H, CH3), 2.51(t, 2H, CH2-Ph), 3.55(t, 2H, CH2-Br), 3.70(s, 3H, OCH3), 6.67d, 1H, 5-H), 6.72(s, 1H, 3-H), 7.01(d, 1H, 6-H).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 14804-31-0.
Reference:
Patent; Hofmeister, Thomas; Reiff, Ulrike; von Hirschheydt, Thomas; Voss, Edgar; US2006/69095; (2006); A1;,
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