Synthetic Route of 2339-58-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2339-58-4 name is 3-Fluoro-5-methoxyaniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
2-Fluoronicotinic acid methyl ester (0.4 g, 2.58 mmol) and 3-fluoro-5-methoxyaniline(0.354 ml, 3.09 mmol) were heated by microwave irradiation at 120 C for 50 mm. 0.1 ml(0.873 mmol) of 3-fluoro-5-methoxyaniline was added and the mixture was irradiated for 30mm at 120 C. Some DCM was added and the mixture was washed twice with H20. Organicphase was dried over Na2SO4, filtered and evaporated. Crude product was purified bytrituration with diethyl ether. 0.293 g of the title compound was obtained.?H NMR (400 MHz, DMSO-d6) 6 ppm 3.78 (s, 3 H) 3.91 (s, 3 H) 6.48 (dt, 1 H) 6.96 (dd, 1H) 7.03 – 7.11 (m, 1 H) 7.42 (dt, 1 H) 8.29 (dd, 1 H) 8.48 (dd, 1 H) 10.20 (s, 1 H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Fluoro-5-methoxyaniline, and friends who are interested can also refer to it.
Reference:
Patent; ORION CORPORATION; ARVELA, Riina; HOLM, Patrik; VESALAINEN, Anniina; WO2015/144976; (2015); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem