Reference of 93919-56-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 93919-56-3 name is (4-(Trifluoromethoxy)phenyl)methanamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
(i) N-[4-(Trifluoromethoxy)benzyl]acetamide To a solution of 4-(trifluoromethoxy)benzylamine (3.46 g, 57.6 mmol) in DMF (75 mL) and acetic acid (10.0 g, 52.3 mmol) at -10 C. were added O-(benzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium tetrafluoroborate (20.2 g, 62.8 mmol) and N,N-diisopropylethylamine (20.0 mL, 115 mmol) and the reaction mixture was stirred at room temperature overnight. Ethyl acetate (200 mL) was added and the organic phase was washed with water (100 mL), 0.25 M NaOH (100 mL), saturated aqueous NaHCO3 (100 mL), water (100 mL), 0.5 M HCl (100 mL), and water (100 mL), dried over MgSO4, and concentrated in vacuo to afford 11.2 g (92%) of a colourless oil. 1H NMR (600 MHz, CDCl3): delta 2.03 (s, 3H), 4.43 (d, 2H), 5.83 (bs, 1H), 7.17 (d, 2H), 7.31 (d, 2H). 13C NMR (125 MHz, CDCl3): delta 22.9, 42.8, 120.5 (q), 121.1, 129.0, 137.3, 148.4, 170.6.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, (4-(Trifluoromethoxy)phenyl)methanamine, and friends who are interested can also refer to it.
Reference:
Patent; Alstermark, Eva-Lotte Lindstedt; Olsson, Anna Christina; Li, Lanna; US2005/282822; (2005); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem