In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 261762-35-0, name is 5-Bromo-1,2-difluoro-3-methoxybenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C7H5BrF2O
The title compound was prepared by reaction of 5-bromo-1,2-difluoro-3-methoxybenzene (1.03 g, 4.62 mmol, 1.0 equiv) andmagnesium (112 mg, 4.61 mmol, 1.0 equiv) and iodine (~2 mg) in13 ml diethylether under reflux for 2 h. Carbon dioxidewas bubbledthrough the solution at 10 C until all solvent (13 ml) was evaporatedtwo times. The crude product was dissolved in 10ml THF andcarbon dioxidewas bubbled through the solution for additional 1 h.The reaction was quenched with 1M HCl, extracted with ethyl acetate,dried with magnesium sulfate and concentrated underreduced pressure to afford the crude product, which was purifiedby flash chromatography; yield: 31% (265 mg). 1H NMR (300 MHz,MeOH-d4) d 7.65e7.45 (m, 2H), 3.99 (s, 3H).
The synthetic route of 261762-35-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Abdelsamie, Ahmed S.; Salah, Mohamed; Siebenbuerger, Lorenz; Hamed, Mostafa M.; Boerger, Carsten; van Koppen, Chris J.; Frotscher, Martin; Hartmann, Rolf W.; European Journal of Medicinal Chemistry; vol. 178; (2019); p. 93 – 107;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem