Electric Literature of 7025-06-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7025-06-1, name is 1-Bromo-2-phenoxybenzene, This compound has unique chemical properties. The synthetic route is as follows.
The 1-bromo-2-phenoxybenzene 0.018 muM is dissolved in 100 ml, in dry THF, added after the never-dried 500 ml three-mouth bottle, N2 -78 °C under the protection of the reaction 30min, slow adds by drops positively BuLi 0.027 muM, after dropping maintain -78 °C reaction 3h, then slowly dropping triisopropyl borate 0.02 muM, after dropping the reaction is maintained in the -78 °C reaction 2h, slow heating to room temperature, the reaction overnight, TLC monitoring after the reaction is completed, water slow quenching the reaction solution, extraction to dryness, to obtain 2-phenoxyphenylboronic acid (B-1) 0.0144 muM, and the yield is 80percent. Mass spectrum: 214.06.
The chemical industry reduces the impact on the environment during synthesis 1-Bromo-2-phenoxybenzene. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Jilin Optical and Electronic MaterialsCo.,Ltd; Cui, Dunzhu; Wang, zhao; Bi, Yan; Qin, Cuiying; Hu, Xiaoming; Gao, Chunji; (43 pag.)CN106565434; (2017); A;,
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