These common heterocyclic compound, 60789-54-0, name is ((4-Bromobutoxy)methyl)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C11H15BrO
. A suspension of NaH (60% in mineral oil, 440 mg, 14 mmol) in DMF [(50] ml) was slowly added to a stirred solution of benzyl-4-bromobutyl ether (3.33g, 13.7 mmol) and amide 26 (5.41 g, 5.48 mmol) (WO 00/66587) in DMF (100 ml) kept at [5C.] The reaction mixture was stirred for 10 h at [50] C, quenched with 5 ml of H20 at [0] C, and evaporated to dryness in vacuo. The residue was taken up in ethyl acetate, washed with [H20,] and purified on a silica gel column using ethyl acetate/hexane: 3/7 as eluant; [5.] [1G, (81%)] of 27 were obatained [;’H-NMR] (CDCl3) : 0.97 (t, J=7. 1 Hz, 3H), 1.2-1. 5 (m, 16H), 2.27 (s, 3H), 2.29 (s, 9H), 2.55 (s, 24H), 2.9-3. 2 (m, 16H), 3.31 (t, J=6.0 Hz), 4.41 (s, 2H), 6.9-7. 0 (m, 8H), 7.2- 7.4 (m, [5H).]
The synthetic route of ((4-Bromobutoxy)methyl)benzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SLIL BIOMEDICAL CORPORATION; WO2004/2991; (2004); A1;,
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