Related Products of 93919-56-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 93919-56-3, name is (4-(Trifluoromethoxy)phenyl)methanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a solution of 4- (trifluoromethoxy) benzylamine (3.46 g, 57.6 mmol) in DMF (75 mL) and acetic acid (10.0 g, 52.3 mmol) at-10 C were added 0- (BENZOTRIAZOL-1-YL)-N, NN’, N’- tetramethyluronium tetrafluoroborate (20.2 g, 62.8 mmol) and NN-DIISOPROPYLETHYLAMINE (20.0 mL, 115 mmol) and the reaction mixture was stirred at room temperature overnight. Ethyl acetate (200 ML) was added and the organic phase was washed with water (100 mL), 0.25 M NAOH (100 mL), saturated aqueous NAHCO3 (100 ML), water (100 mL), 0.5 M HCl (100 ML), and water (100 ML), dried over MgS04, and concentrated in vacuo to afford 11.2 g (92%) of a colourless oil. ‘H NMR (600 MHz, CDC13) : 8 2.03 (s, 3H), 4.43 (d, 2H), 5.83 (bs, 1H), 7.17 (d, 2H), 7.31 (d, 2H). 13C NMR (125 MHZ, CDC13) : 8 22.9, 42.8, 120.5 (q), 121.1, 129.0, 137.3, 148.4, 170.6.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (4-(Trifluoromethoxy)phenyl)methanamine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2004/56748; (2004); A1;,
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