In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 588-96-5, name is p-Bromophenetole belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: p-Bromophenetole
To a solution of 2R-allyl-3S-hydroxy-succinic acid diisopropylester (4.79 g, 18.5 MMOL), 4-bromo PHENETOLE (3.19 MI, 22.2 mmol, 1.2 eq. ) and NEt3 (6.22 ML, 44.6 MMOL, 2.4 eq. ) in CH3CN (40 ml), was added a sonicated (for 2 min) suspension of P (O-TOL) 3 (0.57 g, 2.22 mmol, 0.1 eq. ) and Pd (OAC) 2 (209 mg, 5%) in CH3CN (5 ML). The reaction mixture was heated to reflux for 2 hrs. CH3CN was removed under vacuum. The crude was extracted with AcOEt (3 X 200 ML), washed with water (50 mi) and with brine (50 ML). A purification by flash chromatography afforded the desired 2R- [3- (4-ethoxy-phenyl)-allyl]-3S- hydroxy-succinic acid diisopropyl ester (5.92 g, 84% yield). 1H-NMR ; delta (CDC13), 7.28 (2H, d, J = 8.8Hz), 6.83 (2H, d, J = 8.8Hz), 6.46 (1H, d, J = 15.7Hz), 6.02-6. 12 (1H, m), 4.98-5. 13 (2H, m), 4.26 (1H, dd, J = 7.1, 3. 0HZ), 4.02 (2H, q, J = 7. 0HZ), 3.23 (1H, d, J = 7. 1 HZ), 2.92-2. 97 (1H, m), 2.68-2. 79 (1H, m), 2.49-2. 62 (1H, m), 1.41 (3H, t, J=7.0 Hz) and 1.19- 1.30 (12H, m). LRMS: +ve ion 400 (M+Na).
The synthetic route of 588-96-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BRITISH BIOTECH PHARMACEUTICALS LTD; LABORATOIRES SERONO S.A.; WO2004/101537; (2004); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem