Application of 157869-15-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 157869-15-3, name is 2-((4-Methoxyphenyl)ethynyl)aniline, This compound has unique chemical properties. The synthetic route is as follows.
1 k (0.3 mmol, 67 mg), [RhCp*Cl2] 2 (0.015 mmol, 9.3 mg) and hexafluoroisopropanol (2 mL) were sequentially added to a 15 mL reaction tube.The reaction tube was sealed in an air atmosphere, and the reaction was stirred at 120 C for 20 h. After the completion of the reaction, the reaction tube was cooled to room temperature, and 10 mL of water was added thereto, followed by extraction with ethyl acetate (10 mL × 3), and the organic phase was washed successively with water and brine, and dried over anhydrous sodium sulfate. filter,Spin dry, separated by silica gel column (petroleum ether / ethyl acetate = 5 / 1)The white solid product 2k (35 mg, 72%).
The chemical industry reduces the impact on the environment during synthesis 2-((4-Methoxyphenyl)ethynyl)aniline. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Henan Normal University; Fan Xuesen; Jia Ruixue; Zhang Xinying; Li Bin; (18 pag.)CN110183443; (2019); A;,
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