In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 25245-34-5, name is 2-Bromo-1,4-dimethoxybenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 25245-34-5
To a solution of LDA (7.4 mL, 1.1 eq) in THF (15 mL) were added furan (15 mL) and l-bromo-2,5-dimethoxybenzene (2.16 g, 10 mmol) in turn at -78 C. The mixture was stirred at this temperature for 30 mins and quenched with water and then the mixture was allowed to warm up to rt and extracted with ethyl ether (50 mL x 3). The combined organic layers were dried over anhydrous Na2SC>4 and concentrated in vacuo. The residue was purified by silica gel column chromatography (Hex/EtOAc (v/v) = 1/1) to give the title compound as a white solid (2.1 g, 86%). The compound was characterized by the following spectroscopic data: NMR (400MHz, CDC13) delta 7.06 (2H, s), 6.97 (2H, s), 6.54 (2H, s), 5.92 (2H, s), 3.78 (6H, s) ppm.
The synthetic route of 25245-34-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; ZHANG, Jiancun; XIE, Hongming; REN, Qingyun; HU, Bailin; LI, Shifeng; WU, Xiwei; TANG, Changhua; WANG, Chenglin; FANG, Qinghong; YU, Quanxing; ZHANG, Zhikeng; WO2014/131315; (2014); A1;,
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