Electric Literature of 39021-83-5,Some common heterocyclic compound, 39021-83-5, name is 1,4-Dimethoxy-2,3-dimethylbenzene, molecular formula is C10H14O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 1 2,3-Dimethyl-5,6-dinitro-1,4-dimethoxybenzene A solution of 2,3-dimethyl-1,4-dimethoxybenzene (16.6 g; o.1 mol) in acetic acid (100 mL) was cooled in an ice bath, then conc. HNO3 (40 mL) was added dropwise over 15 minutes. After the addition, the reaction mixture was stirred at ambient temperature for 3 hours, then heated at 50 C. for 20 minutes. Solution was concentrated to 75 mL under vacuum, then poured into ice-H2O (350 mL). The yellow precipitate (8.1 g) was collected. Recrystallization from EtOH gave 5.4 g (18.5% yield) of 2,3-dimethyl-5,6-dinitro-1,4-dimethoxybenzene as a yellow solid, m.p. 147-150 C.
The synthetic route of 39021-83-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Wyeth; US6444694; (2002); B1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem