Some common heterocyclic compound, 19056-40-7, name is 4-Bromo-3-methoxyaniline, molecular formula is C7H8BrNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 4-Bromo-3-methoxyaniline
POCl3 (5.07 ml, 54.4 mmol) was added to a mixture of 4-bromo-3-methoxyaniline (10 g, 49.5 mmol) and malonicacid (5.15 g, 49.5 mmol) with thorough mixing, and the solution was then heated to 105°C. After 5 min, the reactionbegan to bubble vigorously and eventually formed a hard foam, and heating was continued for 1 h. After cooling, water(200 mL) was added, and the mixture was stirred for 30 min. The solid was filtered off and washed with water. 2N NaOH(300 mL) was added to the solid, and stirring was continued overnight. The remaining solid was filtered off. EtOH (5 mL)was then added to the filtrate, and the basic layer was then acidified with concentrated HCl to pH 2. The resulting solidwas then filtered off and washed with water. The solid was then transferred to a flask, and the remaining water wasremoved by stripping off EtOH (200 mL x 2). The solid was then further dried under high vacuum for 15 h to yield 8.75g (66percent) of the title compound as an off-white solid. LRMS ESI+ (M+H)+ 270.2/272.2
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 19056-40-7, its application will become more common.
Reference:
Patent; Merck Sharp & Dohme Corp.; MSD Italia S.r.l.; MCCAULEY, John, A.; LIVERTON, Nigel, J.; HARPER, Steven; MCINTYRE, Charles, A.; RUDD, Michael, T.; (73 pag.)EP2268285; (2018); B1;,
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