Synthetic Route of 89521-55-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 89521-55-1 as follows.
EXAMPLE 27; Ethyl[8-(benzyloxy)-3-oxo-3,4-dihydroquinoxaline-2(1H)-ylidene]acetate 60a; To 3-(benzyloxy)benzene-1,2-diamine (300 mg, 1.4 mmol) in solution in 2 ml of acetic acid, add diethyloxalacetate sodium salt (295 mg, 1.4 mmol) and stir under reflux for 2 hours. Evaporate to dryness and chromatograph to obtain the abovenamed product. Yield: 20%. 1H-NMR (200 MHz, DMSO-d6): delta 11.39 (broad s, 1H, NH), 8.70 (broad s, 1H, NH), 7.53-7.37 (m, 5H arom.), 6.93-6.84 (t, 1H, J=8 Hz, 1H arom.), 6.71-6.67 (d, 1H, J=8 Hz, 1H arom.), 6.57-6.53 (d, 1H, J=8 Hz, 1H arom.), 5.84 (s, 1H, CCH), 5.29 (s, 1H, OCH2-Ph), 4.30-4.20 (q, 2H, J=7 Hz, OCH2-CH3), 1.35-1.28 (t, 3H, J=7 Hz, OCH2CH3).
According to the analysis of related databases, 89521-55-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Schmitt, Martine; Klotz, Evelyne; Macher, Jean-Paul; Bourguignon, Jean-Jacques; Abarghaz, Mustapha; Wagner, Patrick; Ronsin, Gael; US2006/183909; (2006); A1;,
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