In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 10103-06-7 as follows. Application In Synthesis of 2,3-Dimethoxynaphthalene
EXAMPLE 9 2-(4-Chlorobutyl)-6,7-dimethoxynaphthalene Aluminum chloride (25.5 g, 0.19 mole) was added to a solution of 21.5 mL (0.19 mole) of 4-chlorobutyryl chloride in 225 mL of methylene chloride. To the resulting solution, cooled in an ice bath, was added dropwise a solution of 30.0 g (0.16 mole) of 2,3-dimethoxynaphthalene in 150 mL of methylene chloride over 30 minutes. The reaction mixture was stirred at 3 C. for 30 minutes and at 24 C. for 17 hours. The reaction mixture was worked up as Example 5 and the crude product was recrystallized from acetone-hexane, to give 31.5 g (68% yield), mp 98-99, of 4-chloro-1-(6,7-dimethoxy-2-naphthalenyl)-1-butanone. Anal Calcd. for C16 H17 ClO3: C, 65.64; H, 5.85; Cl, 12.11. Found: C, 65.33; H, 5.77; Cl, 12.16.
According to the analysis of related databases, 10103-06-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Hoffmann-La Roche Inc.; US4937371; (1990); A;,
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