Adding a certain compound to certain chemical reactions, such as: 41406-00-2, name is 3-Isopropoxyaniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 41406-00-2, Safety of 3-Isopropoxyaniline
To a stirred solution of 2,6,6-trimethylcyclohex-l-enecarbaldehyde (99.5 mg, 0.66 mmol) in methanol (2 mL) ) was added 3-isopropoxyaniline (99.5 mg, 0.66 mmol) followed by acetic acid (0.1 mL), and sodium cyanoborohydride (124.0 mg, 1.97 mmol). The reaction was stirred at room temperature for 2 hours. The reaction was quenched by addition of saturated aqueous ammonium chloride (5 mL) and the organic volatiles were evaporated under reduced pressure. The resulting mixture was diluted with ethyl acetate (30 mL) and the organic phase was washed with water (20 mL), saturated aqueous sodium bicarbonate (20 mL) and brine (20 mL), dried over anhydrous sodum sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate = 90/1 ) to give the title compound as a colorless oil (137 mg, Yield: 72%). Rf = 0.6 (20:1 petroleum ether/ethyl acetate); H NMR (400 MHz, CDCI3) delta 7.05 (t, J = 8.0 Hz, 1 H), 6.24-6.18 (m, 2 H), 6.15-6.14 (m, 1 H), 4.56-4.50 (m, 1 H), 3.55 (s, 2 H), 3.30 (bs, 1 H), 1.97 (t, J = 6.2 Hz, 2 H), 1.66 (s, 3 H), 1.66-1.59 (m, 2 H), 1.50-1.43 (m, 2 H), 1.33 (d, J = 6.0 Hz, 6 H), .02 (s, 6 H) ppm; Mass spectrum (ESI +ve) m/z 288 (M + H+).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Isopropoxyaniline, and friends who are interested can also refer to it.
Reference:
Patent; BIKAM PHARMACEUTICALS, INC.; QUACH, Tan; BERMAN, Judd; GARVEY, David, S.; WO2013/81642; (2013); A1;,
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