Synthetic Route of 7664-66-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7664-66-6, name is 4-Isopropoxyaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
[Example 45] Preparation of 1-(4-chlorobenzyl)-2-(4-isopropoxyphenylimino)-dihydro-pyrimidine-4,6-dion (I-322) To a mixture of 4-isopropoxyaniline (15 g, 99 mmol) and acetonitrile (150 mL) was added gradually benzoylisothiocyanate (13.4 mL, 99 mmol) under ice-cooling, and the resulting mixture was stirred at room temperature for 50 minutes. To the reaction mixture were added gradually 4-chlorobenzylamine (12.1 mL, 99 mmol), triethylamine (13.8 mL, 99 mmol), and 1-ethyl-3-(3-dimethyl-aminopropyl) carbodiimide hydrochloride (20.9 g, 109 mmol) under ice-cooling, and the resulting mixture was stirred at room temperature for 2.5 hours. To the reaction mixture was added water (200 mL), and the mixture was extracted with toluene (300 mL). The extract was washed by brine (100 mL), dried over anhydrous magnesium sulfate, and concentrated in vacuo. The resulting residue was precipitated by toluene and hexane to give N-((4-chlorobenzylamino)(4-isopropoxyanilino)methylene)benzamide (38.1 g, Yield: 91%) as white powder. 1H-NMR (delta ppm TMS/CDCl3): 1.34 (6H, d, J=6.0 Hz), 4.52 (1H, sept, J=6.0 Hz), 4.72 (2H, d, J=6.2 Hz), 5.09 (1H, brs), 6.87-6.92 (2H, m), 7.13-7.18 (2H, m), 7.24-7.31 (4H, m), 7.36-7.48 (3H, m), 8.21-8.25 (2H, m), 11.9 (1H, brs).
The synthetic route of 4-Isopropoxyaniline has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shionogi & Co., Ltd.; KAI, Hiroyuki; ENDOH, Takeshi; JIKIHARA, Sae; ASAHI, Kentaro; HORIGUCHI, Tohru; EP2604260; (2013); A1;,
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