Adding a certain compound to certain chemical reactions, such as: 929-75-9, name is 1,11-Diamino-3,6,9-trioxaundecane, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 929-75-9, Formula: C8H20N2O3
To 4-carboxymethyl-7-[1-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecyl)-1H-1,2,3-triazol-4-yl]-2H-chromen-2-one (7a, 200 mg, 0.273 mmol) and 1,11-diamino-3,6,9-trioxaundecane (8c, 53 mg, 0.273 mmol) in THF (10 mL) at room temperature was added benzotriazole-1-yl-oxytris(dimethylamino)phosphonium hexafluorophosphate (121 mg, 0.273 mmol), and the mixture was stirred at the same temperature for 1 h. The solvent was removed, and the resulting slurry was diluted with saturated aqueous NaHCO3 and extracted with methylene chloride several times. The combined organic layer was washed with brine, dried over magnesium sulfate, and evaporated in vacuo. The residue was chromatographed on a silica gel column with methylene chloride and MeOH (7:1) to give the desired product 10e (113 mg, 46%). Mp 303.9+/-0.7 C; 1H NMR (500 MHz, DMF-d7): delta=8.92 (s, 1H), 8.44 (br t, J=5.6 Hz, 1H), 7.99 (d, J=8.3 Hz, 1H), 7.94 (dd, J=8.3 and 1.5 Hz, 1H), 7.89 (d, J=1.5 Hz, 1H), 6.52 (s, 1H), 4.74 (t, J=7.0 Hz, 2H), 3.92 (s, 2H), 3.78 (m, 2H), 3.63-3.67(m, 2H), 3.60-3.63 (m, 2H), 3.57-3.60 (m, 4H), 3.55 (t, J=5.6 Hz, 2H), 3.40 (q, J=5.6 Hz, 2H), 3.24-3.33 (m, 2H), 2.43-2.56 (m, 2H), 2.31-2.31 ppm (m, 2H); 13C NMR (125 MHz, DMF-d7): delta=168.4, 160.2, 154.4, 151.1, 145.7, 135.0, 126.6, 123.2, 121.3, 119.1, 116.0, 112.9, 70.35, 70.27, 70.21, 70.18, 69.5, 67.2, 49.1, 40.1, 39.94, 39.91, 39.7, 39.6, 39.5, 39.4, 39.2, 27.8 (t, J=19.2 Hz), 21.6 ppm (t, J=3.5 Hz); IR (ATR, neat): nu=2925, 1719 (CO), 1654 (CO), 1622, 1238, 1203, 1147, 1056, 1027, 1009, 1004, 832, 823, 763 cm-1; MS (ESI): m/z: 906 [M+H+]; HRMS (EI): m/z calcd for C32H32F17N5O6: 905.2081 [M+]; [M+] not found.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,11-Diamino-3,6,9-trioxaundecane, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Jeon, Moon-Kook; Kang, Myoung-Ku; Park, Koon Ha; Tetrahedron; vol. 68; 30; (2012); p. 6038 – 6053;,
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