Application of 1535-75-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1535-75-7 as follows.
General procedure: To a mixture of chloral hydrate (19.9 g, 120 mmol) in water (400 mL) was added Na2SO4(142 g, 1 mol) in portions at 40 C. After becoming homogenous and clear, the mixture was cooled to room temperature. 1 (100 mmol) and concentrated HCl (9 mL) were then added to the resulting solution, followed by a mixture of hydroxylamine hydrochloride (20.9 g, 300 mmol) in water. The solution was heated at reflux for 8 h and then cooled to room temperature. The precipitate was collected and dissolved in a 10 % aqueous NaOH solution. The resulting mixture was filtered through a pad of Celite. The filtrate was acidified to pH = 3 with 6 N HCl. The precipitate was filtered and dried to give the desired product 2.
According to the analysis of related databases, 1535-75-7, the application of this compound in the production field has become more and more popular.
Reference:
Article; Wu, Chang-Chun; Wang, Bao-Lei; Liu, Jing-Bo; Wei, Wei; Li, Yu-Xin; Liu, Yang; Chen, Ming-Gui; Xiong, Li-Xia; Yang, Na; Li, Zheng-Ming; Chinese Chemical Letters; vol. 28; 6; (2017); p. 1248 – 1251;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem