1663-61-2, name is (Triethoxymethyl)benzene, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 1663-61-2
Triethylorthobenzoate (25 g, 0.112 mole), malonitrile (9.07 g, 0.137 mole and acetic anhydride (50 ml) were brought to reflux overnight. The excess acetic anhydride was removed under vacuum and the product was chromatographed over silica gel eluting with 30percent ethylacetate/hexanes to give 21.7 g of product (yield: 97percent)
The synthetic route of 1663-61-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TIBOTEC PHARMACEUTICALS LTD.; WO2006/35061; (2006); A1;,
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