1484-26-0, name is 3-Benzyloxyaniline, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C13H13NO
4-Chloro-6-iodo-7-((2-(trimethylsilyl)ethoxy)methyl)-7Hpyrrolo-[2,3-d]pyrimidine [8] (600 mg, 1.46 mmol) and 3-(benzyloxy)aniline (585 mg, 2.94 mmol) were dissolved in nbutanol(12 mL) under an N2-atmosphere. The reaction mixturewas agitated at 100 °C for 6.5 hours. Following work-up asdescribed in Section 2.4.1, the crude product was purified twiceby silica-gel column chromatography (n-pentane/THF, 9/2, Rf = 0.37). Drying gave 661 mg(1.15 mmol, 79percent) of a orange solid.
The synthetic route of 1484-26-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Reiers°lmoen, Ann Christin; Han, Jin; Sundby, Eirik; Hoff, Bard Helge; European Journal of Medicinal Chemistry; vol. 155; (2018); p. 562 – 578;,
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