Adding a certain compound to certain chemical reactions, such as: 20781-20-8, name is (2,4-Dimethoxyphenyl)methanamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 20781-20-8, COA of Formula: C9H13NO2
To a solution of ethyl (4aS)- 1 -(4-fluorophenyl)-6-oxo-4,5 ,7,8-tetrahydrobenzo [fjindazole-4a- carboxylate (ig) (3.16 g, 8.92 mmol) and (2,4-dimethoxyphenyl)methanamine (2.68 mL, 17.83 mmol) in DCE (40 mL) was added acetic acid (1.54 mL, 26.75 mmol). After the reaction was stirred at rt for 5 mm and cooled down in an ice-bath, sodium triacetoxyborohydride (5.lg, 24.08 mmol) was added in portions. 5 Minute later, the reaction solution was allowed to warm to rt and continued stirring for 30 mm. The solution was quenched (sat. aq. NaHCO3) and extracted (EtOAc). The organic layers were washed (brine), dried (Na2SO4) and concentrated under reduced pressure. The cmde product was purified by silica gel chromatography (Si02, 0%-75 % EtOAc/hexanes, gradient elution) to provide the title compound (lila) (4.15 g, 92% yield) as an off-white solid. mlz (ESI, +ve ion) = 506.3 [M+Hj.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, (2,4-Dimethoxyphenyl)methanamine, and friends who are interested can also refer to it.
Reference:
Patent; ORIC PHARMACEUTICALS, INC.; DU, Xiaohui; EKSTEROWICZ, John; FANTIN, Valeria R.; REW, Yosup; SUN, Daqing; YE, Qiuping; ZHOU, Haiying; KAWAI, Hiroyuki; MOORE, Jared; PHAM, Johnny; WU, Kejia; ZHU, Liusheng; YAMASHITA, Dennis; (288 pag.)WO2018/191283; (2018); A1;,
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