Adding a certain compound to certain chemical reactions, such as: 6096-89-5, name is 2-(4-Fluorophenoxy)ethylamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6096-89-5, Application In Synthesis of 2-(4-Fluorophenoxy)ethylamine
Example 17: (Compound No. 223)Sodium salt of 3-[3-({3-[2-(4-fluorophenoxy)ethyl]-1 -propyl-2,4-dioxo-1 ,2,3,4- tetrahydroquinazolin-6-yl}carbonyl)imidazo[1 ,5-a]pyridin-1 -yl]benzoic acidMethyl 5-[(1 -bromoimidazo[1 ,5-a]pyridin-3-yl)carbonyl]-2-({[2-(4- fluorophenoxy)ethyl]carbamoyl}amino)benzoate4.75 g (16 mmol) of triphosgene are added, at ambient temperature under an inert atmosphere, to 4.99 g (13.33 mmol) of methyl 2-amino-5-({1 -[3- (methoxycarbonyl)phenyl]imidazo[1 ,5-a]pyridin-3-yl}carbonyl)benzoate in 220 ml of dioxane. After refluxing for 5 hours, 6.21 g (40 mmol) of 2-(4-fluorophenoxy)-1 – ethylamine and 4.05 g (40 mmol) of triethylamine are added at ambient temperature. The reaction medium is refluxed for 3 hours and then concentrated under reduced pressure. The residue is triturated from water. After filtration, the solid is rinsed with methanol and then dried under reduced pressure at 40C overnight. 6.67 g of a yellow solid are obtained.MH+: 555
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(4-Fluorophenoxy)ethylamine, and friends who are interested can also refer to it.
Reference:
Patent; SANOFI; ALCOUFFE, Chantal; KIRSCH, Reinhard; HERBERT, Corentin; LASSALE, Gilbert; WO2012/4732; (2012); A1;,
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