Electric Literature of 1535-73-5,Some common heterocyclic compound, 1535-73-5, name is 3-Trifluoromethoxyaniline, molecular formula is C7H6F3NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A microwave vial (2?5mL) was charged with 1 equiv of mon-subtituted triazine in acetonitrile. Then 1.1 equiv of DIPEA and 1 equiv of aryl amine derivative were added. The vial was sealed and heated under microwave irradiated between 10 and 180 min at 150°C. After completion of the reaction (monotored by TLC), the solvent was removed by vacuum evaporation. The resultant mixture was dissolved in EtOAc or CH2Cl2, a solution of 2N HCl was added then water. The layer organic was extracted whit EtOAc or CH2Cl2 and dried with MgSO4, The product was purified by silica gel chromatography or recrisallized in ethanol 95.
The synthetic route of 1535-73-5 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Tber, Zahira; Wartenberg, Mylene; Jacques, Jean-Eddy; Roy, Vincent; Lecaille, Fabien; Warszycki, Dawid; Bojarski, Andrzej J.; Lalmanach, Gilles; Agrofoglio, Luigi A.; Bioorganic and Medicinal Chemistry; vol. 26; 14; (2018); p. 4310 – 4319;,
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